What can one learn from experiments about the elusive transition state?

Iksoo Chang; Marek Cieplak; Jayanth R. Banavar; Amos Maritan

doi:10.1110/ps.04713804

What can one learn from experiments about the elusive transition state?

Iksoo Chang, Marek Cieplak, Jayanth R. Banavar, Amos Maritan

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We present the results of an exact analysis of a model energy landscape of a protein to clarify the idea of the transition state and the physical meaning of the φ values determined in protein engineering experiments. We benchmark our findings to various theoretical approaches proposed in the literature for the identification and characterization of the transition state.

Original language	English
Pages (from-to)	2446-2457
Number of pages	12
Journal	Protein Science
Volume	13
Issue number	9
DOIs	https://doi.org/10.1110/ps.04713804
State	Published - Sep 2004

Keywords

Protein engineering
Protein folding
Transition state

Access to Document

10.1110/ps.04713804

Cite this

@article{4efc9715ef934bf6a07623d1178664b2,

title = "What can one learn from experiments about the elusive transition state?",

abstract = "We present the results of an exact analysis of a model energy landscape of a protein to clarify the idea of the transition state and the physical meaning of the φ values determined in protein engineering experiments. We benchmark our findings to various theoretical approaches proposed in the literature for the identification and characterization of the transition state.",

keywords = "Protein engineering, Protein folding, Transition state",

author = "Iksoo Chang and Marek Cieplak and Banavar, \{Jayanth R.\} and Amos Maritan",

year = "2004",

month = sep,

doi = "10.1110/ps.04713804",

language = "English",

volume = "13",

pages = "2446--2457",

journal = "Protein Science",

issn = "0961-8368",