Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Mark R. Hartman; Dayong Yang; Thua N.N. Tran; Kwang Lee; Jason S. Kahn; Pichamon Kiatwuthinon; Kenneth G. Yancey; Oleksandr Trotsenko; Sergiy Minko; Dan Luo

doi:10.1002/anie.201302175

Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Mark R. Hartman, Dayong Yang, Thua N.N. Tran, Kwang Lee, Jason S. Kahn, Pichamon Kiatwuthinon, Kenneth G. Yancey, Oleksandr Trotsenko, Sergiy Minko, Dan Luo

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

Original language	English
Pages (from-to)	8699-8702
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	33
DOIs	https://doi.org/10.1002/anie.201302175
State	Published - 12 Aug 2013

Keywords

DNA structures
hydrogels
nanotechnology
nucleic acids
polymerase chain reaction

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title = "Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction",

abstract = "Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.",

keywords = "DNA structures, hydrogels, nanotechnology, nucleic acids, polymerase chain reaction",

author = "Hartman, \{Mark R.\} and Dayong Yang and Tran, \{Thua N.N.\} and Kwang Lee and Kahn, \{Jason S.\} and Pichamon Kiatwuthinon and Yancey, \{Kenneth G.\} and Oleksandr Trotsenko and Sergiy Minko and Dan Luo",

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T1 - Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

AU - Hartman, Mark R.

AU - Yang, Dayong

AU - Tran, Thua N.N.

AU - Lee, Kwang

AU - Kahn, Jason S.

AU - Kiatwuthinon, Pichamon

AU - Yancey, Kenneth G.

AU - Trotsenko, Oleksandr

AU - Minko, Sergiy

AU - Luo, Dan

PY - 2013/8/12

Y1 - 2013/8/12

N2 - Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

AB - Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

KW - DNA structures

KW - hydrogels

KW - nanotechnology

KW - nucleic acids

KW - polymerase chain reaction

UR - https://www.scopus.com/pages/publications/84882310975

U2 - 10.1002/anie.201302175

DO - 10.1002/anie.201302175

M3 - Article

C2 - 23825018

AN - SCOPUS:84882310975

SN - 1433-7851

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SP - 8699

EP - 8702

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Abstract

Keywords

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