Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Mark R. Hartman; Dayong Yang; Thua N.N. Tran; Kwang Lee; Jason S. Kahn; Pichamon Kiatwuthinon; Kenneth G. Yancey; Oleksandr Trotsenko; Sergiy Minko; Dan Luo

doi:10.1002/anie.201302175

Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Mark R. Hartman, Dayong Yang, Thua N.N. Tran, Kwang Lee, Jason S. Kahn, Pichamon Kiatwuthinon, Kenneth G. Yancey, Oleksandr Trotsenko, Sergiy Minko, Dan Luo

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

Original language	English
Pages (from-to)	8699-8702
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	33
DOIs	https://doi.org/10.1002/anie.201302175
State	Published - 12 Aug 2013

Keywords

DNA structures
hydrogels
nanotechnology
nucleic acids
polymerase chain reaction

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abstract = "Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.",

keywords = "DNA structures, hydrogels, nanotechnology, nucleic acids, polymerase chain reaction",

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AU - Hartman, Mark R.

AU - Yang, Dayong

AU - Tran, Thua N.N.

AU - Lee, Kwang

AU - Kahn, Jason S.

AU - Kiatwuthinon, Pichamon

AU - Yancey, Kenneth G.

AU - Trotsenko, Oleksandr

AU - Minko, Sergiy

AU - Luo, Dan

PY - 2013/8/12

Y1 - 2013/8/12

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AB - Chemical cross-linking was used to prepare DNA nanostructures with enhanced thermal stability. These thermostable DNA nanostructures were then utilized as modular primers in the polymerase chain reaction (PCR; see picture), thus enabling the production of multifunctionalized and branched PCR products for multiplexed detection and hydrogel formation.

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KW - hydrogels

KW - nanotechnology

KW - nucleic acids

KW - polymerase chain reaction

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Thermostable branched DNA nanostructures as modular primers for polymerase chain reaction

Abstract

Keywords

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