Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Yongcheol Cho; Valentina Di Liberto; Dan Carlin; Namiko Abe; Kathy H. Li; Alma L. Burlingame; Shenheng Guan; Izhak Michaelevski; Valeria Cavalli

doi:10.1074/jbc.M113.536607

Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Yongcheol Cho
, Valentina Di Liberto
, Dan Carlin
, Namiko Abe
, Kathy H. Li
, Alma L. Burlingame
, Shenheng Guan
, Izhak Michaelevski
, Valeria Cavalli

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

Original language	English
Pages (from-to)	15820-15832
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.536607
State	Published - 30 May 2014

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title = "Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration",

abstract = "Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.",

author = "Yongcheol Cho and \{Di Liberto\}, Valentina and Dan Carlin and Namiko Abe and Li, \{Kathy H.\} and Burlingame, \{Alma L.\} and Shenheng Guan and Izhak Michaelevski and Valeria Cavalli",

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T1 - Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

AU - Cho, Yongcheol

AU - Di Liberto, Valentina

AU - Carlin, Dan

AU - Abe, Namiko

AU - Li, Kathy H.

AU - Burlingame, Alma L.

AU - Guan, Shenheng

AU - Michaelevski, Izhak

AU - Cavalli, Valeria

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

AB - Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

UR - https://www.scopus.com/pages/publications/84901720884

U2 - 10.1074/jbc.M113.536607

DO - 10.1074/jbc.M113.536607

M3 - Article

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AN - SCOPUS:84901720884

SN - 0021-9258

VL - 289

SP - 15820

EP - 15832

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

ER -

Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Abstract

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