Sub-100-ps structural dynamics of horse heart myoglobin probed by time-resolved X-ray solution scattering

Key Young Oang, Kyung Hwan Kim, Junbeom Jo, Youngmin Kim, Jong Goo Kim, Tae Wu Kim, Sunhong Jun, Jeongho Kim, Hyotcherl Ihee

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Here we report sub-100-ps structural dynamics of horse heart myoglobin revealed by time-resolved X-ray solution scattering. By applying the time-slicing scheme to the measurement and subsequent deconvolution, we investigate the protein structural dynamics that occur faster than the X-ray temporal pulse width of synchrotrons (∼100 ps). The singular value decomposition analysis of the experimental data suggests that two structurally distinguishable intermediates are formed within 100 ps. In particular, the global structural change occurring on the time scale of 70 ps is identified.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalChemical Physics
Volume442
DOIs
StatePublished - 17 Oct 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.

Keywords

  • Myoglobin
  • Structural dynamics
  • Time-resolved X-ray solution scattering
  • Time-slicing

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