Signaling silence - Breaking ground and spreading out

Ryun Woo Hye; Eric J. Richards

doi:10.1101/gad.1694608

Signaling silence - Breaking ground and spreading out

Ryun Woo Hye, Eric J. Richards

Department of New Biology

Washington University St. Louis

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Among the persistent mysteries in epigenetics are the criteria by which specific regions of the genome are chosen for deposition of distinguishing chromatin marks. Once a particular region is modified, will the newly acquired epigenetic state spill onto neighboring regions of the genome or be confined to tidy patches? The report by Henderson and Jacobsen in the the previous issue of Genes & Development (pp. 1597-1606) addresses these questions while providing insight into the utility of DNA methylation for a eukaryotic genome.

Original language	English
Pages (from-to)	1719-1723
Number of pages	5
Journal	Genes and Development
Volume	22
Issue number	13
DOIs	https://doi.org/10.1101/gad.1694608
State	Published - 1 Jul 2008

Keywords

DNA methylation
Epigenetics
Gene silencing
siRNA

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10.1101/gad.1694608

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Signaling silence - Breaking ground and spreading out

Abstract

Keywords

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