Role of deubiquitinating enzymes in DNA repair

Younghoon Kee, Tony T. Huang

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.

Original languageEnglish
Pages (from-to)524-544
Number of pages21
JournalMolecular and Cellular Biology
Volume36
Issue number4
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016, American Society for Microbiology. All Rights Reserved.

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