Remission of proteinuria with treatment of Actinomyces infection: Eradicating a cause of secondary membranous glomerulopathy suppresses nephrotic syndrome

Eradication of a cause of secondary membranous glomerulopathy might suppress nephrotic syndrome. Here we report a patient with membranous nephropathy (MN), whose proteinuria entered complete remission after treating actinomycosis. A 45-year-old woman presented with nephrotic syndrome and was diagnosed as having MN. Her urine protein excretion was 5.3 gday and the serum creatinine level was 70.7 μmolL. When we searched for causes of secondary MN, pelvic actinomycosis was detected. After removing the pelvic abscess surgically, we administered amoxicillin for 6 months. Then, her proteinuria had decreased to <0.1 gday, and since it entered remission, she has not relapsed.