Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Byung Chang Suh; Bertil Hille

doi:10.1016/j.conb.2005.05.005

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

Byung Chang Suh, Bertil Hille

Department of Brain Sciences

University of Washington

Research output: Contribution to journal › Review article › peer-review

387 Scopus citations

Abstract

Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

Original language	English
Pages (from-to)	370-378
Number of pages	9
Journal	Current Opinion in Neurobiology
Volume	15
Issue number	3 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.conb.2005.05.005
State	Published - Jun 2005

Bibliographical note

Funding Information:
We thank L Miller for technical assistance. This work was supported by grants NS08174 and AR17803 from the National Institutes of Health.

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10.1016/j.conb.2005.05.005

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title = "Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate",

abstract = "Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.",

author = "Suh, {Byung Chang} and Bertil Hille",

note = "Funding Information: We thank L Miller for technical assistance. This work was supported by grants NS08174 and AR17803 from the National Institutes of Health. ",

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AU - Hille, Bertil

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N2 - Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

AB - Phosphatidylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphatidylinositol 4,5-bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

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U2 - 10.1016/j.conb.2005.05.005

DO - 10.1016/j.conb.2005.05.005

M3 - Review article

C2 - 15922587

AN - SCOPUS:20444428008

SN - 0959-4388

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SP - 370

EP - 378

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

IS - 3 SPEC. ISS.

ER -

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

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