TY - GEN
T1 - Realistic computational modeling for hybrid biopolymer microcantilevers
AU - Kim, Jinseok
AU - Park, Jungyul
AU - Ryu, Suk Kyu
AU - Baek, Jeongeun
AU - Park, Sewan
AU - Kim, Hyeon Cheol
AU - Chun, Kukjin
AU - Park, Sukho
PY - 2006
Y1 - 2006
N2 - Three dimensional cultures in a microfabricated environment provide in vivo-like conditions to cells, and have used in a variety of applications in basic and clinical studies. Also, the analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static FEM analysis and the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.
AB - Three dimensional cultures in a microfabricated environment provide in vivo-like conditions to cells, and have used in a variety of applications in basic and clinical studies. Also, the analysis of the contractility of cardiomyocytes is important for understanding the mechanism of heart failure as well as the molecular alterations in diseased heart cells. This paper presents a realistic computational model, which considers the three dimensional fluid-structural interactions (FSI), to quantify the contractile force of cardiomyocytes on hybrid biopolymer microcantilevers. Prior to this study, only static modeling of the microscale cellular force has been reported. This study modeled the dynamics of cardiomyocytes on microcantilevers in a medium using the FSI. This realistic model was compared with static FEM analysis and the experimental results. Using harmonic response analysis in FSI modeling, the motion of a hybrid biopolymer microcantilever in the medium was identified as a second-order system and the influence of the dynamics of cardiomyocytes could be evaluated quantitatively.
UR - https://www.scopus.com/pages/publications/34047159496
U2 - 10.1109/IEMBS.2006.260177
DO - 10.1109/IEMBS.2006.260177
M3 - Conference contribution
C2 - 17946496
AN - SCOPUS:34047159496
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2102
EP - 2105
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -