RAD51 wrestles with SUMO

Younghoon Kee; Jung Hee Lee; Ho Jin You

doi:10.1080/23723556.2022.2054263

RAD51 wrestles with SUMO

Younghoon Kee
, Jung Hee Lee
, Ho Jin You

Department of New Biology

Chosun University

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.

Original language	English
Article number	2054263
Journal	Molecular and Cellular Oncology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2022.2054263
State	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

RAD51
SUMO

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/23723556.2022.2054263

Cite this

@article{f72f22c080944eed91d4133e17993ec2,

title = "RAD51 wrestles with SUMO",

abstract = "RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.",

keywords = "RAD51, SUMO",

author = "Younghoon Kee and Lee, \{Jung Hee\} and You, \{Ho Jin\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2022",

doi = "10.1080/23723556.2022.2054263",

language = "English",

volume = "9",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - RAD51 wrestles with SUMO

AU - Kee, Younghoon

AU - Lee, Jung Hee

AU - You, Ho Jin

PY - 2022

Y1 - 2022

N2 - RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.

AB - RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.

KW - RAD51

KW - SUMO

UR - https://www.scopus.com/pages/publications/85127645916

U2 - 10.1080/23723556.2022.2054263

DO - 10.1080/23723556.2022.2054263

M3 - Comment/debate

AN - SCOPUS:85127645916

SN - 2372-3556

VL - 9

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - 2054263

ER -

RAD51 wrestles with SUMO

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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