Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

Hyun Ju Lim; Sung Jun Lee; Han Gon Choi; Jung Ae Kim; Chul Soon Yong; Sung Soo Han; Seok Kyun Noh; Jinho Jang; Won Seok Lyoo

doi:10.1002/app.25991

Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

Hyun Ju Lim, Sung Jun Lee, Han Gon Choi, Jung Ae Kim, Chul Soon Yong, Sung Soo Han, Seok Kyun Noh, Jinho Jang, Won Seok Lyoo

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density.

Original language	English
Pages (from-to)	3268-3272
Number of pages	5
Journal	Journal of Applied Polymer Science
Volume	106
Issue number	5
DOIs	https://doi.org/10.1002/app.25991
State	Published - 5 Dec 2007

Keywords

High-molecular weight
Ketoprofen
a-PVA gel

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10.1002/app.25991

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title = "Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels",

abstract = "High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density.",

keywords = "High-molecular weight, Ketoprofen, a-PVA gel",

author = "Lim, {Hyun Ju} and Lee, {Sung Jun} and Choi, {Han Gon} and Kim, {Jung Ae} and Yong, {Chul Soon} and Han, {Sung Soo} and Noh, {Seok Kyun} and Jinho Jang and Lyoo, {Won Seok}",

year = "2007",

month = dec,

day = "5",

doi = "10.1002/app.25991",

language = "English",

volume = "106",

pages = "3268--3272",

journal = "Journal of Applied Polymer Science",

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T1 - Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

AU - Lim, Hyun Ju

AU - Lee, Sung Jun

AU - Choi, Han Gon

AU - Kim, Jung Ae

AU - Yong, Chul Soon

AU - Han, Sung Soo

AU - Noh, Seok Kyun

AU - Jang, Jinho

AU - Lyoo, Won Seok

PY - 2007/12/5

Y1 - 2007/12/5

N2 - High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density.

AB - High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density.

KW - High-molecular weight

KW - Ketoprofen

KW - a-PVA gel

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DO - 10.1002/app.25991

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SN - 0021-8995

VL - 106

SP - 3268

EP - 3272

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

IS - 5

ER -

Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

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Keywords

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