Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

Hyun Ju Lim, Sung Jun Lee, Han Gon Choi, Jung Ae Kim, Chul Soon Yong, Sung Soo Han, Seok Kyun Noh, Jinho Jang, Won Seok Lyoo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density.

Original languageEnglish
Pages (from-to)3268-3272
Number of pages5
JournalJournal of Applied Polymer Science
Volume106
Issue number5
DOIs
StatePublished - 5 Dec 2007

Keywords

  • High-molecular weight
  • Ketoprofen
  • a-PVA gel

Fingerprint

Dive into the research topics of 'Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels'. Together they form a unique fingerprint.

Cite this