PI(4,5)P2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in β Cells

Byung Chang Suh, Jun Hee Yeon, Cheon Gyu Park

Research output: Contribution to journalShort surveypeer-review

Abstract

The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells.

Original languageEnglish
Pages (from-to)753-755
Number of pages3
JournalCell Chemical Biology
Volume23
Issue number7
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

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