PI(4,5)P2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in β Cells

Byung Chang Suh; Jun Hee Yeon; Cheon Gyu Park

doi:10.1016/j.chembiol.2016.07.001

PI(4,5)P₂ and L-type Ca²⁺ Channels Partner Up to Fine-Tune Ca²⁺ Dynamics in β Cells

Byung Chang Suh, Jun Hee Yeon, Cheon Gyu Park

Department of Brain Sciences

Daegu Gyeongbuk Institute of Science and Technology

Research output: Contribution to journal › Short survey › peer-review

Abstract

The PI(4,5)P₂ level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P₂ and reveal how acute PI(4,5)P₂ changes can alter intracellular Ca²⁺ dynamics and insulin secretion in pancreatic β cells.

Original language	English
Pages (from-to)	753-755
Number of pages	3
Journal	Cell Chemical Biology
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.chembiol.2016.07.001
State	Published - 2016

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© 2016 Elsevier Ltd

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title = "PI(4,5)P2 and L-type Ca2+ Channels Partner Up to Fine-Tune Ca2+ Dynamics in β Cells",

abstract = "The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells.",

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AU - Yeon, Jun Hee

AU - Park, Cheon Gyu

PY - 2016

Y1 - 2016

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AB - The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca2+ dynamics and insulin secretion in pancreatic β cells.

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PI(4,5)P₂ and L-type Ca²⁺ Channels Partner Up to Fine-Tune Ca²⁺ Dynamics in β Cells

Abstract

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