Physical limits of pure superparamagnetic Fe 3O 4 nanoparticles for a local hyperthermia agent in nanomedicine

Minhong Jeun; Sanghoon Lee; Jae Kyeong Kang; Asahi Tomitaka; Keon Wook Kang; Young Il Kim; Yasushi Takemura; Kyung Won Chung; Jiyeon Kwak; Seongtae Bae

doi:10.1063/1.3689751

Physical limits of pure superparamagnetic Fe ₃O ₄ nanoparticles for a local hyperthermia agent in nanomedicine

Minhong Jeun, Sanghoon Lee, Jae Kyeong Kang, Asahi Tomitaka, Keon Wook Kang, Young Il Kim, Yasushi Takemura, Kyung Won Chung, Jiyeon Kwak, Seongtae Bae

Department of Robotics and Mechatronics Engineering

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Magnetic and AC magnetically induced heating characteristics of Fe ₃O ₄ nanoparticles (IONs) with different mean diameters, d, systematically controlled from 4.2 to 22.5 nm were investigated to explore the physical relationship between magnetic phase and specific loss power (SLP) for hyperthermia agent applications. It was experimentally confirmed that the IONs had three magnetic phases and correspondingly different SLP characteristics depending on the particle sizes. Furthermore, it was demonstrated that pure superparamagnetic phase IONs (d < 9.8 nm) showed insufficient SLPs critically limiting for hyperthermia applications due to smaller AC hysteresis loss power (Néel relaxation loss power) originated from lower out-of-phase magnetic susceptibility.

Original language	English
Article number	092406
Journal	Applied Physics Letters
Volume	100
Issue number	9
DOIs	https://doi.org/10.1063/1.3689751
State	Published - 27 Feb 2012

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abstract = "Magnetic and AC magnetically induced heating characteristics of Fe 3O 4 nanoparticles (IONs) with different mean diameters, d, systematically controlled from 4.2 to 22.5 nm were investigated to explore the physical relationship between magnetic phase and specific loss power (SLP) for hyperthermia agent applications. It was experimentally confirmed that the IONs had three magnetic phases and correspondingly different SLP characteristics depending on the particle sizes. Furthermore, it was demonstrated that pure superparamagnetic phase IONs (d < 9.8 nm) showed insufficient SLPs critically limiting for hyperthermia applications due to smaller AC hysteresis loss power (N{\'e}el relaxation loss power) originated from lower out-of-phase magnetic susceptibility.",

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AU - Jeun, Minhong

AU - Lee, Sanghoon

AU - Kyeong Kang, Jae

AU - Tomitaka, Asahi

AU - Wook Kang, Keon

AU - Il Kim, Young

AU - Takemura, Yasushi

AU - Chung, Kyung Won

AU - Kwak, Jiyeon

AU - Bae, Seongtae

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Physical limits of pure superparamagnetic Fe ₃O ₄ nanoparticles for a local hyperthermia agent in nanomedicine

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