Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Nikunj Bhatt; Nisarg Soni; Yeong Su Ha; Woonghee Lee; Darpan N. Pandya; Swarbhanu Sarkar; Jung Young Kim; Hochun Lee; Sun Hee Kim; Gwang Il An; Jeongsoo Yoo

doi:10.1021/acsmedchemlett.5b00362

Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Nikunj Bhatt
, Nisarg Soni
, Yeong Su Ha
, Woonghee Lee
, Darpan N. Pandya
, Swarbhanu Sarkar
, Jung Young Kim
, Hochun Lee
, Sun Hee Kim
, Gwang Il An
, Jeongsoo Yoo

Department of Energy and Science and Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, ⁶⁴Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

Original language	English
Pages (from-to)	1162-1166
Number of pages	5
Journal	ACS Medicinal Chemistry Letters
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/acsmedchemlett.5b00362
State	Published - 20 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

Keywords

Bifunctional chelator
phosphonate pendant arms
propylene cross bridge
radiopharmaceuticals

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10.1021/acsmedchemlett.5b00362

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title = "Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64",

abstract = "A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).",

keywords = "Bifunctional chelator, phosphonate pendant arms, propylene cross bridge, radiopharmaceuticals",

author = "Nikunj Bhatt and Nisarg Soni and Ha, \{Yeong Su\} and Woonghee Lee and Pandya, \{Darpan N.\} and Swarbhanu Sarkar and Kim, \{Jung Young\} and Hochun Lee and Kim, \{Sun Hee\} and An, \{Gwang Il\} and Jeongsoo Yoo",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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doi = "10.1021/acsmedchemlett.5b00362",

language = "English",

volume = "6",

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journal = "ACS Medicinal Chemistry Letters",

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TY - JOUR

T1 - Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam

T2 - Synthesis and Evaluation as a Chelator for Cu-64

AU - Bhatt, Nikunj

AU - Soni, Nisarg

AU - Ha, Yeong Su

AU - Lee, Woonghee

AU - Pandya, Darpan N.

AU - Sarkar, Swarbhanu

AU - Kim, Jung Young

AU - Lee, Hochun

AU - Kim, Sun Hee

AU - An, Gwang Il

AU - Yoo, Jeongsoo

PY - 2015/10/20

Y1 - 2015/10/20

N2 - A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

AB - A propylene cross-bridged macrocyclic chelator with two phosphonate pendant arms (PCB-TE2P) was synthesized from cyclam. Various properties of the synthesized chelator, including Cu-complexation, Cu-complex stability, 64Cu-radiolabeling, and in vivo behavior, were studied and compared with those of a previously reported propylene cross-bridged chelator (PCB-TE2A).

KW - Bifunctional chelator

KW - phosphonate pendant arms

KW - propylene cross bridge

KW - radiopharmaceuticals

UR - https://www.scopus.com/pages/publications/84947259180

U2 - 10.1021/acsmedchemlett.5b00362

DO - 10.1021/acsmedchemlett.5b00362

M3 - Article

AN - SCOPUS:84947259180

SN - 1948-5875

VL - 6

SP - 1162

EP - 1166

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 11

ER -

Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64

Abstract

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Keywords

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