P11 and its role in depression and therapeutic responses to antidepressants

Per Svenningsson; Yong Kim; Jennifer Warner-Schmidt; Yong Seok Oh; Paul Greengard

doi:10.1038/nrn3564

P11 and its role in depression and therapeutic responses to antidepressants

Per Svenningsson
, Yong Kim
, Jennifer Warner-Schmidt
, Yong Seok Oh
, Paul Greengard

Department of Brain Sciences

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.

Original language	English
Pages (from-to)	673-680
Number of pages	8
Journal	Nature Reviews Neuroscience
Volume	14
Issue number	10
DOIs	https://doi.org/10.1038/nrn3564
State	Published - Oct 2013

Bibliographical note

Funding Information:
We acknowledge the important contributions of N. Heintz, E. Schmidt, D. Patel, P. Gao and M. Kaplitt to our understanding of the various functions of p11. This work was supported by the Fisher Center for Alzheimer’s Research Foundation (P.S. and P.G.), W81XWH‑09‑1‑0402 (P.G.), NIH MH090963 (P.G.), NIDA1RC2DA028968 (P.G.), The JPB Foundation (P.G.), W81XWH‑09‑1‑0392 (Y.K.), W81XWH‑09‑1‑0401 (J.L.W.‑S.), and Swedish Research Council (P.S.). We apologize to the authors of the many inter‑ esting studies that could not be included owing to space constraints.

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title = "P11 and its role in depression and therapeutic responses to antidepressants",

abstract = "Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.",

author = "Per Svenningsson and Yong Kim and Jennifer Warner-Schmidt and Oh, \{Yong Seok\} and Paul Greengard",

note = "Funding Information: We acknowledge the important contributions of N. Heintz, E. Schmidt, D. Patel, P. Gao and M. Kaplitt to our understanding of the various functions of p11. This work was supported by the Fisher Center for Alzheimer{\textquoteright}s Research Foundation (P.S. and P.G.), W81XWH‑09‑1‑0402 (P.G.), NIH MH090963 (P.G.), NIDA1RC2DA028968 (P.G.), The JPB Foundation (P.G.), W81XWH‑09‑1‑0392 (Y.K.), W81XWH‑09‑1‑0401 (J.L.W.‑S.), and Swedish Research Council (P.S.). We apologize to the authors of the many inter‑ esting studies that could not be included owing to space constraints.",

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doi = "10.1038/nrn3564",

language = "English",

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AU - Svenningsson, Per

AU - Kim, Yong

AU - Warner-Schmidt, Jennifer

AU - Oh, Yong Seok

AU - Greengard, Paul

N1 - Funding Information: We acknowledge the important contributions of N. Heintz, E. Schmidt, D. Patel, P. Gao and M. Kaplitt to our understanding of the various functions of p11. This work was supported by the Fisher Center for Alzheimer’s Research Foundation (P.S. and P.G.), W81XWH‑09‑1‑0402 (P.G.), NIH MH090963 (P.G.), NIDA1RC2DA028968 (P.G.), The JPB Foundation (P.G.), W81XWH‑09‑1‑0392 (Y.K.), W81XWH‑09‑1‑0401 (J.L.W.‑S.), and Swedish Research Council (P.S.). We apologize to the authors of the many inter‑ esting studies that could not be included owing to space constraints.

PY - 2013/10

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N2 - Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.

AB - Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.

UR - https://www.scopus.com/pages/publications/84884586454

U2 - 10.1038/nrn3564

DO - 10.1038/nrn3564

M3 - Review article

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SP - 673

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JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

IS - 10

ER -

P11 and its role in depression and therapeutic responses to antidepressants

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