TY - JOUR
T1 - Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization
AU - Han, Kyung Ah
AU - Ko, Jaewon
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/6
Y1 - 2023/6
N2 - The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
AB - The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
UR - https://www.scopus.com/pages/publications/85160749779
U2 - 10.1038/s12276-023-01004-1
DO - 10.1038/s12276-023-01004-1
M3 - Review article
C2 - 37258575
AN - SCOPUS:85160749779
SN - 1226-3613
VL - 55
SP - 1065
EP - 1075
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 6
ER -