On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases

Van Duc Pham; Jung Hyung Lee; Doyun Shin; Hung M. Vu; Junyang Jung; Manoj K. Kashyap; Seung Hyeun Lee; Min Sik Kim

doi:10.1002/prca.70003

On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases

Van Duc Pham
, Jung Hyung Lee
, Doyun Shin
, Hung M. Vu
, Junyang Jung
, Manoj K. Kashyap
, Seung Hyeun Lee
, Min Sik Kim

Department of New Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry-based proteomics has been applied to profile the BALF proteomes to identify novel biomarkers for lung diseases. This review discusses the current progress in the field of BALF proteomics and highlights its potential as a valuable source of biomarkers for different lung diseases. Additionally, we explored the latest advancements and findings from BALF studies. Finally, we address the current limitations and propose future directions and research opportunities to advance the study of BALF.

Original language	English
Article number	e70003
Journal	Proteomics - Clinical Applications
Volume	19
Issue number	3
DOIs	https://doi.org/10.1002/prca.70003
State	Published - May 2025

Bibliographical note

Publisher Copyright:
© 2025 Wiley-VCH GmbH.

Keywords

BALF
Biomarkers
COPD
Lung Cancer
Lung Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/prca.70003

Cite this

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title = "On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases",

abstract = "Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry-based proteomics has been applied to profile the BALF proteomes to identify novel biomarkers for lung diseases. This review discusses the current progress in the field of BALF proteomics and highlights its potential as a valuable source of biomarkers for different lung diseases. Additionally, we explored the latest advancements and findings from BALF studies. Finally, we address the current limitations and propose future directions and research opportunities to advance the study of BALF.",

keywords = "BALF, Biomarkers, COPD, Lung Cancer, Lung Disease",

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doi = "10.1002/prca.70003",

language = "English",

volume = "19",

journal = "Proteomics - Clinical Applications",

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T1 - On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases

AU - Pham, Van Duc

AU - Lee, Jung Hyung

AU - Shin, Doyun

AU - Vu, Hung M.

AU - Jung, Junyang

AU - Kashyap, Manoj K.

AU - Lee, Seung Hyeun

AU - Kim, Min Sik

PY - 2025/5

Y1 - 2025/5

N2 - Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry-based proteomics has been applied to profile the BALF proteomes to identify novel biomarkers for lung diseases. This review discusses the current progress in the field of BALF proteomics and highlights its potential as a valuable source of biomarkers for different lung diseases. Additionally, we explored the latest advancements and findings from BALF studies. Finally, we address the current limitations and propose future directions and research opportunities to advance the study of BALF.

AB - Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in the BALF remains largely unexplored. Recently, mass spectrometry-based proteomics has been applied to profile the BALF proteomes to identify novel biomarkers for lung diseases. This review discusses the current progress in the field of BALF proteomics and highlights its potential as a valuable source of biomarkers for different lung diseases. Additionally, we explored the latest advancements and findings from BALF studies. Finally, we address the current limitations and propose future directions and research opportunities to advance the study of BALF.

KW - BALF

KW - Biomarkers

KW - COPD

KW - Lung Cancer

KW - Lung Disease

UR - https://www.scopus.com/pages/publications/105000303510

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DO - 10.1002/prca.70003

M3 - Review article

C2 - 40098318

AN - SCOPUS:105000303510

SN - 1862-8346

VL - 19

JO - Proteomics - Clinical Applications

JF - Proteomics - Clinical Applications

IS - 3

M1 - e70003

ER -

On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases

Abstract

Bibliographical note

Keywords

UN SDGs

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