TY - GEN
T1 - Noninvasive diffuse optical measurement of hemodynamic parameters during photodaynamic therapy
AU - Dong, Jing
AU - Ho, Jun Hui
AU - Ting, Siong Luong
AU - Thong, Patricia S.P.
AU - Lee, Kijoon
PY - 2011
Y1 - 2011
N2 - We present a novel multi-modal portable instrument incorporating both diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS), which enables simultaneous monitoring hemodynamic changes in deep tissue and provides a real-time feedback on therapeutic efficacy. By applying this instrument, a pilot experiment based on a predefined PDT protocol which uses Chlorine e6 (Ce6) as the photosensitizer, has been performed. The results showed that Ce6-mediated PDT treatment reduce the blood flow and blood oxygen saturation and increase the total hemoglobin concentration. These preliminary results suggest diffuse optical measurements permit real-time non-invasive monitoring the in vivo hemodynamic changes, thereby enabling early prediction of treatment efficacy of PDT.
AB - We present a novel multi-modal portable instrument incorporating both diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS), which enables simultaneous monitoring hemodynamic changes in deep tissue and provides a real-time feedback on therapeutic efficacy. By applying this instrument, a pilot experiment based on a predefined PDT protocol which uses Chlorine e6 (Ce6) as the photosensitizer, has been performed. The results showed that Ce6-mediated PDT treatment reduce the blood flow and blood oxygen saturation and increase the total hemoglobin concentration. These preliminary results suggest diffuse optical measurements permit real-time non-invasive monitoring the in vivo hemodynamic changes, thereby enabling early prediction of treatment efficacy of PDT.
UR - https://www.scopus.com/pages/publications/79952520037
U2 - 10.3850/978-981-08-7615-9-BS07
DO - 10.3850/978-981-08-7615-9-BS07
M3 - Conference contribution
AN - SCOPUS:79952520037
SN - 9789810876159
T3 - ISOB 2011 - Proceedings of the 1st International Symposium ISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering
SP - 41
EP - 48
BT - ISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering
T2 - 1st International Symposium on Bioengineering, ISOB 2011
Y2 - 19 January 2011 through 19 January 2011
ER -