NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Tunazzina Zaman Khan; Shekh Md Newaj; Ashikur Rahman; Rahnuma Tabassum; Khandaker Nujhat Tasnim; Hasan Mahmud Reza; Md Selim Reza; Seonki Hong; Shazid Md Sharker

doi:10.1039/d3ma00375b

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Tunazzina Zaman Khan
, Shekh Md Newaj
, Ashikur Rahman
, Rahnuma Tabassum
, Khandaker Nujhat Tasnim
, Hasan Mahmud Reza
, Md Selim Reza
, Seonki Hong
, Shazid Md Sharker

Department of Physics and Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm³). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care.

Original language	English
Pages (from-to)	5175-5183
Number of pages	9
Journal	Materials Advances
Volume	4
Issue number	21
DOIs	https://doi.org/10.1039/d3ma00375b
State	Published - 20 Sep 2023

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Publisher Copyright:
© 2023 RSC.

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@article{d86c87357a1144dca01cce626a54c50b,

title = "NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice",

abstract = "In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm3). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care.",

author = "Khan, \{Tunazzina Zaman\} and Newaj, \{Shekh Md\} and Ashikur Rahman and Rahnuma Tabassum and Tasnim, \{Khandaker Nujhat\} and Reza, \{Hasan Mahmud\} and Reza, \{Md Selim\} and Seonki Hong and Sharker, \{Shazid Md\}",

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year = "2023",

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doi = "10.1039/d3ma00375b",

language = "English",

volume = "4",

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T1 - NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

AU - Khan, Tunazzina Zaman

AU - Newaj, Shekh Md

AU - Rahman, Ashikur

AU - Tabassum, Rahnuma

AU - Tasnim, Khandaker Nujhat

AU - Reza, Hasan Mahmud

AU - Reza, Md Selim

AU - Hong, Seonki

AU - Sharker, Shazid Md

PY - 2023/9/20

Y1 - 2023/9/20

N2 - In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm3). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care.

AB - In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm3). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care.

UR - https://www.scopus.com/pages/publications/85174283371

U2 - 10.1039/d3ma00375b

DO - 10.1039/d3ma00375b

M3 - Article

AN - SCOPUS:85174283371

SN - 2633-5409

VL - 4

SP - 5175

EP - 5183

JO - Materials Advances

JF - Materials Advances

IS - 21

ER -

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Abstract

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