Abstract
We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.
Original language | English |
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Article number | #332689 |
Pages (from-to) | 4539-4551 |
Number of pages | 13 |
Journal | Biomedical Optics Express |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - 1 Sep 2018 |
Bibliographical note
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