Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: A diffuse correlation spectroscopy study

Yumie Ono, Kimiya Esaki, Yuta Takahashi, Mikie Nakabayashi, Masashi Ichinose, Kijoon Lee

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.

Original languageEnglish
Article number#332689
Pages (from-to)4539-4551
Number of pages13
JournalBiomedical Optics Express
Volume9
Issue number9
DOIs
StatePublished - 1 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 Optical Society of America.

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