TY - JOUR
T1 - Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
AU - Lugano, D.
AU - Barrett, L.
AU - Westerheide, S. D.
AU - Kee, Y.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/2
Y1 - 2024/2
N2 - The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology.
AB - The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology.
UR - https://www.scopus.com/pages/publications/85181231009
U2 - 10.1038/s12276-023-01139-1
DO - 10.1038/s12276-023-01139-1
M3 - Review article
C2 - 38172598
AN - SCOPUS:85181231009
SN - 1226-3613
VL - 56
SP - 59
EP - 65
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 1
ER -
