Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy

Eunkyeong Jung, Changsun Kang, Jeonghun Lee, Donghyuck Yoo, Do Won Hwang, Dohyun Kim, Seong Cheol Park, Sang Kyoo Lim, Chulgyu Song, Dongwon Lee

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an elevated level of hydrogen peroxide (H2O2), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H2O2-triggered photoacoustic signal amplification and serve as an antithrombotic nanomedicine. T-FBM nanoparticles were designed to target fibrin-rich thrombi and be activated by H2O2 to generate CO2 bubbles to amplify the photoacoustic signal. In the phantom studies, T-FBM nanoparticles showed significant amplification of ultrasound/photoacoustic signals in a H2O2-triggered manner. T-FBM nanoparticles also exerted H2O2-activatable antioxidant, anti-inflammatory, and antiplatelet activities on endothelial cells. In mouse models of carotid arterial injury, T-FBM nanoparticles significantly enhanced the photoacoustic contrast specifically in thrombosed vessels and significantly suppressed thrombus formation. We anticipate that T-FBM nanoparticles hold great translational potential as nanotheranostics for H2O2-associated cardiovascular diseases.

Original languageEnglish
Pages (from-to)392-401
Number of pages10
JournalACS Nano
Volume12
Issue number1
DOIs
StatePublished - 23 Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

Keywords

  • antithrombotic
  • nanoparticles
  • photoacoustic imaging
  • theranostic
  • thrombus

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