TY - JOUR
T1 - Modulation mechanisms of voltage-gated calcium channels
AU - Park, Cheon Gyu
AU - Suh, Byung Chang
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Voltage-gated calcium (CaV) channels mediate diverse essential physiological functions through membrane depolarization-induced Ca2+ influx. Malfunction of CaV channels causes various pathophysiological disorders. A wide range of cellular signals, including phosphoinositides, auxiliary CaV β subunits, Ca2+/calmodulin, and phosphorylation, are crucial for finely controlling the activity of CaV channels. Various interacting proteins, such as 14-3-3 protein, densin, and stac3, are also important in regulating the surface expression of CaV channels. Here, this review provides recent advances in the regulatory mechanisms of CaV channel gating and trafficking.
AB - Voltage-gated calcium (CaV) channels mediate diverse essential physiological functions through membrane depolarization-induced Ca2+ influx. Malfunction of CaV channels causes various pathophysiological disorders. A wide range of cellular signals, including phosphoinositides, auxiliary CaV β subunits, Ca2+/calmodulin, and phosphorylation, are crucial for finely controlling the activity of CaV channels. Various interacting proteins, such as 14-3-3 protein, densin, and stac3, are also important in regulating the surface expression of CaV channels. Here, this review provides recent advances in the regulatory mechanisms of CaV channel gating and trafficking.
UR - https://www.scopus.com/pages/publications/85051031208
U2 - 10.1016/j.cophys.2018.01.005
DO - 10.1016/j.cophys.2018.01.005
M3 - Review article
AN - SCOPUS:85051031208
SN - 2468-8681
VL - 2
SP - 77
EP - 83
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -