Abstract
We demonstrate a separation method for complex mixture of superparamagnetic beads using half-disk pathways, under an in-plane rotating magnetic field, which is highly sensitive to the bead size and magnetic susceptibility. The non-linear dynamics of the beads moving along the half-disk pathways at multiple frequencies can be divided into three regimes: a phase-locked regime at low driving frequencies, a phase-slipping regime above the first critical frequency fc1, and a phase-insulated regime above the second critical frequency fc2 in which the beads just hop at the gaps between two half-disks. Hence, based on the dynamical motions, the beads with varied sizes or heterogenic magnetic properties can be separated efficiently. Furthermore, a bio-selective separation of bead plus human monocytic leukemia (THP-1) cell complexes from bare beads has been achieved due to the increased drag force on the complexes, resulting in a decreased critical frequency.
Original language | English |
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Article number | 7579139 |
Journal | IEEE Magnetics Letters |
Volume | 7 |
DOIs | |
State | Published - 2016 |
Bibliographical note
Publisher Copyright:© 2010-2012 IEEE.
Keywords
- Biomagnetics
- cells
- in-plane rotating field
- multi-frequencies
- separation
- superparamagnetic beads