Microchip filter using 3-Dimensional flow for rare cells separation

June Young Lee, Hui Sung Moon, Tae Seok Sim, Minseok S. Kim, Hyoyoung Jeong, Yeon Jeong Kim, Jeong Gun Lee, Sanghyun Baek, Jin Mi Oh, Hun Joo Lee, Jea Chan Park, Nam Huh, Soo Suk Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper describes a novel microchip filter device incorporating slit arrays and 3-dimensional flow that can separate rare cells with high efficiency and throughput. The proposed device has several tens of times increased throughput, and has a unique pressure distribution along the filter pore, inducing target cells to be captured and gently lined up at the end of the slit in relatively low shear stress condition. With the enhanced capture yield and throughput, the proposed device can be used as an efficient rare-cell-analyzing tool for blood-based diagnostics.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1111-1113
Number of pages3
ISBN (Print)9780979806452
StatePublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • 3-D flow
  • Filter
  • Rare cells

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