Mechanism of doxorubicin-induced cell death and expression profile analysis

Seongeun Lee; Myungin Baek; Hae Yeong Kim; Ji Hong Ha; Doo Il Jeoung

doi:10.1023/A:1016174800956

Mechanism of doxorubicin-induced cell death and expression profile analysis

Seongeun Lee, Myungin Baek, Hae Yeong Kim, Ji Hong Ha, Doo Il Jeoung

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We characterized doxorubicin-induced cell death in gastric cancer cells. It induced apoptotic phenotypes including poly(ADP-ribose) polymerase cleavage, and activation of caspases. By using cDNA microarray analysis, we identified 18 genes that are induced by doxorubicin in at least four of nine gastric cancer cell lines.

Original language	English
Pages (from-to)	1147-1151
Number of pages	5
Journal	Biotechnology Letters
Volume	24
Issue number	14
DOIs	https://doi.org/10.1023/A:1016174800956
State	Published - 2002

Keywords

Apoptosis
CDNA microarray
Doxorubicin
Gastric cancer cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1016174800956

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title = "Mechanism of doxorubicin-induced cell death and expression profile analysis",

abstract = "We characterized doxorubicin-induced cell death in gastric cancer cells. It induced apoptotic phenotypes including poly(ADP-ribose) polymerase cleavage, and activation of caspases. By using cDNA microarray analysis, we identified 18 genes that are induced by doxorubicin in at least four of nine gastric cancer cell lines.",

keywords = "Apoptosis, CDNA microarray, Doxorubicin, Gastric cancer cells",

author = "Seongeun Lee and Myungin Baek and Kim, {Hae Yeong} and Ha, {Ji Hong} and Jeoung, {Doo Il}",

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AU - Lee, Seongeun

AU - Baek, Myungin

AU - Kim, Hae Yeong

AU - Ha, Ji Hong

AU - Jeoung, Doo Il

PY - 2002

Y1 - 2002

N2 - We characterized doxorubicin-induced cell death in gastric cancer cells. It induced apoptotic phenotypes including poly(ADP-ribose) polymerase cleavage, and activation of caspases. By using cDNA microarray analysis, we identified 18 genes that are induced by doxorubicin in at least four of nine gastric cancer cell lines.

AB - We characterized doxorubicin-induced cell death in gastric cancer cells. It induced apoptotic phenotypes including poly(ADP-ribose) polymerase cleavage, and activation of caspases. By using cDNA microarray analysis, we identified 18 genes that are induced by doxorubicin in at least four of nine gastric cancer cell lines.

KW - Apoptosis

KW - CDNA microarray

KW - Doxorubicin

KW - Gastric cancer cells

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U2 - 10.1023/A:1016174800956

DO - 10.1023/A:1016174800956

M3 - Article

AN - SCOPUS:0036325542

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VL - 24

SP - 1147

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JO - Biotechnology Letters

JF - Biotechnology Letters

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ER -

Mechanism of doxorubicin-induced cell death and expression profile analysis

Abstract

Keywords

UN SDGs

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