Magnetically Enhanced Intracellular Uptake of Superparamagnetic Iron Oxide Nanoparticles for Antitumor Therapy

Junhee Choi, Dong In Kim, Jin Young Kim, Salvador Pané, Bradley J. Nelson, Young Tae Chang, Hongsoo Choi

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed in biomedical fields, including targeted delivery of antitumor therapy. Conventional magnetic tumor targeting has used simple static magnetic fields (SMFs), which cause SPIONs to linearly aggregate into a long chain-like shape. Such agglomeration greatly hinders the intracellular targeting of SPIONs into tumors, thus reducing the therapeutic efficacy. In this study, we investigated the enhancement of the intracellular uptake of SPIONs through the application of rotating magnetic fields (RMFs). Based on the physical principles of SPION chain disassembly, we investigated physical parameters to predict the chain length favorable for intracellular uptake. Our prediction was validated by clear visualization of the intracellular distributions of SPIONs in tumor cells at both cellular and three-dimensional microtissue levels. To identify the potential therapeutic effects of enhanced intracellular uptake, magnetic hyperthermia as antitumor therapy was investigated under varying conditions of magnetic hyperthermia and RMFs. The results showed that enhanced intracellular uptake reduced magnetic hyperthermia time and strength as well as particle concentration. The proposed method will be useful in the development of techniques to determine the optimized physical conditions for the enhanced intracellular uptake of SPIONs in antitumor therapy.

Original languageEnglish
Pages (from-to)15857-15870
Number of pages14
JournalACS Nano
Volume17
Issue number16
DOIs
StatePublished - 22 Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Keywords

  • chain disassembly
  • intracellular uptake
  • magnetic hyperthermia
  • rotating magnetic field
  • tumor targeting

Fingerprint

Dive into the research topics of 'Magnetically Enhanced Intracellular Uptake of Superparamagnetic Iron Oxide Nanoparticles for Antitumor Therapy'. Together they form a unique fingerprint.

Cite this