Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery

Ki Won Gyak; Sungwoong Jeon; Laura Ha; Sangwon Kim; Jin young Kim; Kwang Sup Lee; Hongsoo Choi; Dong Pyo Kim

doi:10.1002/adhm.201900739

Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery

Ki Won Gyak
, Sungwoong Jeon
, Laura Ha
, Sangwon Kim
, Jin young Kim
, Kwang Sup Lee
, Hongsoo Choi
, Dong Pyo Kim

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.

Original language	English
Article number	1900739
Journal	Advanced Healthcare Materials
Volume	8
Issue number	21
DOIs	https://doi.org/10.1002/adhm.201900739
State	Published - 1 Nov 2019

Bibliographical note

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

biocompatible materials
cell delivery
ceramic microrobots
magnetic nanoparticles
silicon carbonitride

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10.1002/adhm.201900739

Cite this

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title = "Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery",

abstract = "A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.",

keywords = "biocompatible materials, cell delivery, ceramic microrobots, magnetic nanoparticles, silicon carbonitride",

author = "Gyak, \{Ki Won\} and Sungwoong Jeon and Laura Ha and Sangwon Kim and Kim, \{Jin young\} and Lee, \{Kwang Sup\} and Hongsoo Choi and Kim, \{Dong Pyo\}",

note = "Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = nov,

day = "1",

doi = "10.1002/adhm.201900739",

language = "English",

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journal = "Advanced Healthcare Materials",

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T1 - Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery

AU - Gyak, Ki Won

AU - Jeon, Sungwoong

AU - Ha, Laura

AU - Kim, Sangwon

AU - Kim, Jin young

AU - Lee, Kwang Sup

AU - Choi, Hongsoo

AU - Kim, Dong Pyo

PY - 2019/11/1

Y1 - 2019/11/1

N2 - A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.

AB - A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface-modified ceramic carrier by thiol-ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells.

KW - biocompatible materials

KW - cell delivery

KW - ceramic microrobots

KW - magnetic nanoparticles

KW - silicon carbonitride

UR - https://www.scopus.com/pages/publications/85074027687

U2 - 10.1002/adhm.201900739

DO - 10.1002/adhm.201900739

M3 - Article

C2 - 31596550

AN - SCOPUS:85074027687

SN - 2192-2640

VL - 8

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

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M1 - 1900739

ER -

Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery

Abstract

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Keywords

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