Magnetically actuated microrobots as a platform for stem cell transplantation

Sungwoong Jeon; Sangwon Kim; Shinwon Ha; Seungmin Lee; Eunhee Kim; So Yeun Kim; Sun Hwa Park; Jung Ho Jeon; Sung Won Kim; Cheil Moon; Bradley J. Nelson; Jin young Kim; Seong Woon Yu; Hongsoo Choi

doi:10.1126/scirobotics.aav4317

Magnetically actuated microrobots as a platform for stem cell transplantation

Sungwoong Jeon, Sangwon Kim, Shinwon Ha, Seungmin Lee, Eunhee Kim, So Yeun Kim, Sun Hwa Park, Jung Ho Jeon, Sung Won Kim, Cheil Moon, Bradley J. Nelson, Jin young Kim, Seong Woon Yu, Hongsoo Choi

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.

Original language	English
Article number	eaav4317
Journal	Science Robotics
Volume	4
Issue number	30
DOIs	https://doi.org/10.1126/scirobotics.aav4317
State	Published - 29 May 2019

Bibliographical note

Publisher Copyright:
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/scirobotics.aav4317

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title = "Magnetically actuated microrobots as a platform for stem cell transplantation",

abstract = "Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.",

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doi = "10.1126/scirobotics.aav4317",

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AU - Jeon, Sungwoong

AU - Kim, Sangwon

AU - Ha, Shinwon

AU - Lee, Seungmin

AU - Kim, Eunhee

AU - Kim, So Yeun

AU - Park, Sun Hwa

AU - Jeon, Jung Ho

AU - Kim, Sung Won

AU - Moon, Cheil

AU - Nelson, Bradley J.

AU - Kim, Jin young

AU - Yu, Seong Woon

AU - Choi, Hongsoo

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AB - Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.

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Magnetically actuated microrobots as a platform for stem cell transplantation

Abstract

Bibliographical note

UN SDGs

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