Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Hyun Chul Kim; Eunjoo Kim; Sang Won Jeong; Tae Lin Ha; Sang Im Park; Se Guen Lee; Sung Jun Lee; Seung Woo Lee

doi:10.1039/c5nr04130a

Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Hyun Chul Kim, Eunjoo Kim, Sang Won Jeong, Tae Lin Ha, Sang Im Park, Se Guen Lee, Sung Jun Lee, Seung Woo Lee

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64 Scopus citations

Abstract

Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.

Original language	English
Pages (from-to)	16470-16480
Number of pages	11
Journal	Nanoscale
Volume	7
Issue number	39
DOIs	https://doi.org/10.1039/c5nr04130a
State	Published - 21 Oct 2015

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© The Royal Society of Chemistry.

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title = "Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy",

abstract = "Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.",

author = "Kim, {Hyun Chul} and Eunjoo Kim and Jeong, {Sang Won} and Ha, {Tae Lin} and Park, {Sang Im} and Lee, {Se Guen} and Lee, {Sung Jun} and Lee, {Seung Woo}",

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T1 - Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

AU - Kim, Hyun Chul

AU - Kim, Eunjoo

AU - Jeong, Sang Won

AU - Ha, Tae Lin

AU - Park, Sang Im

AU - Lee, Se Guen

AU - Lee, Sung Jun

AU - Lee, Seung Woo

PY - 2015/10/21

Y1 - 2015/10/21

N2 - Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.

AB - Magnetic nanoparticle-conjugated polymeric micelles (MNP-PMs) consisting of poly(ethylene glycol)-poly(lactide) (PEG-PLA) and iron oxide nanoparticles were prepared and used as nanocarriers for combined hyperthermia and chemotherapy. Doxorubicin (DOX) was encapsulated in MNP-PMs, and an alternating magnetic field (AMF) resulted in an increase to temperature within a suitable range for inducing hyperthermia and a higher rate of drug release than observed without AMF. In vitro cytotoxicity and hyperthermia experiments were carried out using human lung adenocarcinoma A549 cells. When MNP-PMs encapsulated with an anticancer drug were used to treat A549 cells in combination with hyperthermia under AMF, 78% of the cells were killed by the double effects of heat and the drug, and the combination was more effective than either chemotherapy or hyperthermia treatment alone. Therefore, MNP-PMs encapsulated with an anticancer drug show potential for combined chemotherapy and hyperthermia.

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SN - 2040-3364

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SP - 16470

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JO - Nanoscale

JF - Nanoscale

IS - 39

ER -

Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

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