Leucine-rich repeat proteins of synapses

Jaewon Ko, Eunjoon Kim

Research output: Contribution to journalShort surveypeer-review

44 Scopus citations

Abstract

Leucine-rich repeats (LRRs) are 20-29-aa motifs that mediate protein-protein interactions and are present in a variety of membrane and cytoplasmic proteins. Many LRR proteins with neuronal functions have been reported. Here, we summarize an emerging group of synaptic LRR proteins, which includes densin-180, Erbin, NGL, SALM, and LGI1. These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses.

Original languageEnglish
Pages (from-to)2824-2832
Number of pages9
JournalJournal of Neuroscience Research
Volume85
Issue number13
DOIs
StatePublished - Oct 2007

Keywords

  • Cell adhesion molecule
  • Densin-180
  • Erbin
  • LGI1
  • LRR
  • NGL
  • SALM

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