LAR-RPTPs: Synaptic adhesion molecules that shape synapse development

Ji Won Um; Jaewon Ko

doi:10.1016/j.tcb.2013.07.004

LAR-RPTPs: Synaptic adhesion molecules that shape synapse development

Department of Brain Sciences

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.

Original language	English
Pages (from-to)	465-475
Number of pages	11
Journal	Trends in Cell Biology
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.tcb.2013.07.004
State	Published - Oct 2013

Bibliographical note

Funding Information:
The authors are grateful for the critical comments of members of the Ko laboratory, Drs Seok-kyu Kwon and Jungyong Nam, and Ms Min Ah Han on an earlier version of this manuscript. This work was supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea (A120590 and A120723 to J.K.), the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2011-0028337 to J.K.), a Junior Faculty Fellowship from the POSCO TJ Park Foundation (to J.K.), and the Yonsei University Research Fund of 2013 (to J.W.U.).

Keywords

LAR
PTPδ
PTPσ
Receptor protein tyrosine phosphatase
Synapse
Synaptic adhesion

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10.1016/j.tcb.2013.07.004

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title = "LAR-RPTPs: Synaptic adhesion molecules that shape synapse development",

abstract = "The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.",

keywords = "LAR, PTPδ, PTPσ, Receptor protein tyrosine phosphatase, Synapse, Synaptic adhesion",

author = "Um, \{Ji Won\} and Jaewon Ko",

note = "Funding Information: The authors are grateful for the critical comments of members of the Ko laboratory, Drs Seok-kyu Kwon and Jungyong Nam, and Ms Min Ah Han on an earlier version of this manuscript. This work was supported by grants from the Korea Healthcare Technology R\&D Project, Ministry for Health \& Welfare Affairs, Republic of Korea (A120590 and A120723 to J.K.), the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2011-0028337 to J.K.), a Junior Faculty Fellowship from the POSCO TJ Park Foundation (to J.K.), and the Yonsei University Research Fund of 2013 (to J.W.U.).",

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AB - The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.

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KW - Synaptic adhesion

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DO - 10.1016/j.tcb.2013.07.004

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EP - 475

JO - Trends in Cell Biology

JF - Trends in Cell Biology

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ER -

LAR-RPTPs: Synaptic adhesion molecules that shape synapse development

Abstract

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Keywords

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