Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers

Min Pyeong Kim, Swatilekha Kayal, Chiwon Hwang, Jonghoon Bae, Hyunseok Kim, Dong Gyu Hwang, Min Ho Jeon, Jeong Kon Seo, Dowon Ahn, Wonjoo Lee, Sangwon Seo, Joong Hyun Chun, Youngchang Yu, Sung You Hong

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials.

Original languageEnglish
Article number3381
JournalNature Communications
Volume15
Issue number1
DOIs
StatePublished - Dec 2024

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© The Author(s) 2024.

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