In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles

Hasan Al Faruque; Eun Sook Choi; Jung Hee Kim; Soonhyun Kim; Eunjoo Kim

doi:10.2217/nnm-2019-0085

In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles

Hasan Al Faruque, Eun Sook Choi, Jung Hee Kim, Soonhyun Kim, Eunjoo Kim

Daegu Gyeongbuk Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for their Cs adsorption properties in vitro and in vivo. The distribution of the adsorbents was also evaluated in C57BL/6 mice. Results: PB-deposited MNPs provided an improved adsorbent capacity for Cs removal and reduced toxicity to blood cells compared with those of bulk PB. Conclusion: PB-deposited MNPs could be considered as an alternative of PB-based medicine to reduce the possible hazards caused by high dose of PB intake.

Original language	English
Pages (from-to)	3143-3158
Number of pages	16
Journal	Nanomedicine
Volume	14
Issue number	24
DOIs	https://doi.org/10.2217/nnm-2019-0085
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 Future Medicine Ltd.

Keywords

Prussian blue
in vivo
iron oxide nanoparticles
radioactive cesium

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10.2217/nnm-2019-0085

Cite this

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title = "In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles",

abstract = "Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for their Cs adsorption properties in vitro and in vivo. The distribution of the adsorbents was also evaluated in C57BL/6 mice. Results: PB-deposited MNPs provided an improved adsorbent capacity for Cs removal and reduced toxicity to blood cells compared with those of bulk PB. Conclusion: PB-deposited MNPs could be considered as an alternative of PB-based medicine to reduce the possible hazards caused by high dose of PB intake.",

keywords = "Prussian blue, in vivo, iron oxide nanoparticles, radioactive cesium",

author = "Faruque, {Hasan Al} and Choi, {Eun Sook} and Kim, {Jung Hee} and Soonhyun Kim and Eunjoo Kim",

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year = "2019",

doi = "10.2217/nnm-2019-0085",

language = "English",

volume = "14",

pages = "3143--3158",

journal = "Nanomedicine",

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TY - JOUR

T1 - In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles

AU - Faruque, Hasan Al

AU - Choi, Eun Sook

AU - Kim, Jung Hee

AU - Kim, Soonhyun

AU - Kim, Eunjoo

PY - 2019

Y1 - 2019

N2 - Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for their Cs adsorption properties in vitro and in vivo. The distribution of the adsorbents was also evaluated in C57BL/6 mice. Results: PB-deposited MNPs provided an improved adsorbent capacity for Cs removal and reduced toxicity to blood cells compared with those of bulk PB. Conclusion: PB-deposited MNPs could be considered as an alternative of PB-based medicine to reduce the possible hazards caused by high dose of PB intake.

AB - Aim: To mitigate the side effects of medical treatment by Prussian blue (PB), a well-known adsorbent for radioactive cesium (Cs), PB-deposited magnetic nanoparticles (MNPs), were prepared and analyzed on the adsorbent capacity for Cs removal. Materials & methods: The PB-deposited MNPs were prepared by photo-deposition method and investigated for their Cs adsorption properties in vitro and in vivo. The distribution of the adsorbents was also evaluated in C57BL/6 mice. Results: PB-deposited MNPs provided an improved adsorbent capacity for Cs removal and reduced toxicity to blood cells compared with those of bulk PB. Conclusion: PB-deposited MNPs could be considered as an alternative of PB-based medicine to reduce the possible hazards caused by high dose of PB intake.

KW - Prussian blue

KW - in vivo

KW - iron oxide nanoparticles

KW - radioactive cesium

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DO - 10.2217/nnm-2019-0085

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SN - 1743-5889

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JO - Nanomedicine

JF - Nanomedicine

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ER -

In vivo removal of radioactive cesium compound using Prussian blue-deposited iron oxide nanoparticles

Abstract

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Keywords

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