In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids

S. I. Park; J. H. Lim; Y. H. Hwang; K. H. Kim; S. M. Kim; J. H. Kim; C. G. Kim; C. O. Kim

doi:10.1002/pssc.200777126

In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids

S. I. Park, J. H. Lim, Y. H. Hwang, K. H. Kim, S. M. Kim, J. H. Kim, C. G. Kim, C. O. Kim

Department of Physics and Chemistry

Chungnam National University

Research output: Contribution to journal › Conference article › peer-review

9 Scopus citations

Abstract

Doxorubicin-loaded magnetic particles with lecithin and polyethylene glycol as an interlayer were synthesized by multi-step process of high temperature thermal decomposition and ultrasonic, respectively. The change of particle size and the magnetic property were investigated for the estimation of the carrier characteristic with doxorubicin addition. And, the loading efficiency of drug and the loaded drug released fraction were discussed for the estimation of drug effect. Also, the remedial efficiency of adsorbed drug on the magnetic nanoparticle was investigated by comparing the cytotoxicity of tumor cell between bare-and doxorubicin-loaded magnetic nanoparticles. And, in-vivo test was performed to estimate the effect of anticancer therapy by using C57BL/6 mice as an animal sample.

Original language	English
Pages (from-to)	4345-4351
Number of pages	7
Journal	Physica Status Solidi (C) Current Topics in Solid State Physics
Volume	4
Issue number	12
DOIs	https://doi.org/10.1002/pssc.200777126
State	Published - 2007
Event	International Symposium on Advanced Magnetic Materials and Appilications, (ISAMMA 2007) - Jeju, Korea, Republic of Duration: 28 May 2007 → 1 Jun 2007

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10.1002/pssc.200777126

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title = "In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids",

abstract = "Doxorubicin-loaded magnetic particles with lecithin and polyethylene glycol as an interlayer were synthesized by multi-step process of high temperature thermal decomposition and ultrasonic, respectively. The change of particle size and the magnetic property were investigated for the estimation of the carrier characteristic with doxorubicin addition. And, the loading efficiency of drug and the loaded drug released fraction were discussed for the estimation of drug effect. Also, the remedial efficiency of adsorbed drug on the magnetic nanoparticle was investigated by comparing the cytotoxicity of tumor cell between bare-and doxorubicin-loaded magnetic nanoparticles. And, in-vivo test was performed to estimate the effect of anticancer therapy by using C57BL/6 mice as an animal sample.",

author = "Park, {S. I.} and Lim, {J. H.} and Hwang, {Y. H.} and Kim, {K. H.} and Kim, {S. M.} and Kim, {J. H.} and Kim, {C. G.} and Kim, {C. O.}",

year = "2007",

doi = "10.1002/pssc.200777126",

language = "English",

volume = "4",

pages = "4345--4351",

journal = "Physica Status Solidi (C) Current Topics in Solid State Physics",

issn = "1862-6351",

publisher = "Wiley-VCH Verlag",

number = "12",

note = "International Symposium on Advanced Magnetic Materials and Appilications, (ISAMMA 2007) ; Conference date: 28-05-2007 Through 01-06-2007",

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TY - JOUR

T1 - In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids

AU - Park, S. I.

AU - Lim, J. H.

AU - Hwang, Y. H.

AU - Kim, K. H.

AU - Kim, S. M.

AU - Kim, J. H.

AU - Kim, C. G.

AU - Kim, C. O.

PY - 2007

Y1 - 2007

N2 - Doxorubicin-loaded magnetic particles with lecithin and polyethylene glycol as an interlayer were synthesized by multi-step process of high temperature thermal decomposition and ultrasonic, respectively. The change of particle size and the magnetic property were investigated for the estimation of the carrier characteristic with doxorubicin addition. And, the loading efficiency of drug and the loaded drug released fraction were discussed for the estimation of drug effect. Also, the remedial efficiency of adsorbed drug on the magnetic nanoparticle was investigated by comparing the cytotoxicity of tumor cell between bare-and doxorubicin-loaded magnetic nanoparticles. And, in-vivo test was performed to estimate the effect of anticancer therapy by using C57BL/6 mice as an animal sample.

AB - Doxorubicin-loaded magnetic particles with lecithin and polyethylene glycol as an interlayer were synthesized by multi-step process of high temperature thermal decomposition and ultrasonic, respectively. The change of particle size and the magnetic property were investigated for the estimation of the carrier characteristic with doxorubicin addition. And, the loading efficiency of drug and the loaded drug released fraction were discussed for the estimation of drug effect. Also, the remedial efficiency of adsorbed drug on the magnetic nanoparticle was investigated by comparing the cytotoxicity of tumor cell between bare-and doxorubicin-loaded magnetic nanoparticles. And, in-vivo test was performed to estimate the effect of anticancer therapy by using C57BL/6 mice as an animal sample.

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DO - 10.1002/pssc.200777126

M3 - Conference article

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VL - 4

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EP - 4351

JO - Physica Status Solidi (C) Current Topics in Solid State Physics

JF - Physica Status Solidi (C) Current Topics in Solid State Physics

IS - 12

T2 - International Symposium on Advanced Magnetic Materials and Appilications, (ISAMMA 2007)

Y2 - 28 May 2007 through 1 June 2007

ER -

In vivo and in vitro antitumor activity of doxorubicin-loaded magnetic fluids

Abstract

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