TY - JOUR
T1 - Hyaluronic acid catechol
T2 - A biopolymer exhibiting a pH-dependent adhesive or cohesive property for human neural stem cell engineering
AU - Hong, Seonki
AU - Yang, Kisuk
AU - Kang, Bobae
AU - Lee, Changhyun
AU - Song, In Taek
AU - Byun, Eunkyoung
AU - Park, Kook In
AU - Cho, Seung Woo
AU - Lee, Haeshin
PY - 2013/4/12
Y1 - 2013/4/12
N2 - Nature has developed materials that are integrated and effective at controlling their properties of adhesiveness and cohesiveness; the chemistry of these materials has been optimized during evolution. For example, a catechol moiety found in the adhesive proteins of marine mussels regulates its properties between adhesion and cohesion, rapidly adapting to environmental conditions. However, in synthetic materials chemistry, introduced chemical moieties are usually monofunctional, either being adhesive or cohesive; typically, this is not effective compared to natural materials. Herein, it is demonstrated that hyaluronic acid-catechol (HA-catechol) conjugates can exhibit either adhesiveness, functionalizing the surface of materials, or cohesiveness, building 3D hydrogels. Up to now, catechol-conjugated polymers have shown to be useful in one of these two functions. The usefulness of the polymer in stem cell engineering is demonstrated. A platform for neural stem cell culture may be prepared, utilizing the adhesive property of HA-catechol, and hydrogels are fabricated to encapsulate the neural stem cells, utilizing the cohesive property of the HA conjugate. Moreover, the HA-catechol hydrogels are highly neural stem cell compatible, showing better viability compared to existing methods based on HA hydrogels. Hyaluronic acid catechol conjugate is able to change between adhesiveness and cohesiveness in a smart way. This is demonstrated to be useful for human neural stem cell culture, which cannot be stably cultured on typical polystyrene culture plates.
AB - Nature has developed materials that are integrated and effective at controlling their properties of adhesiveness and cohesiveness; the chemistry of these materials has been optimized during evolution. For example, a catechol moiety found in the adhesive proteins of marine mussels regulates its properties between adhesion and cohesion, rapidly adapting to environmental conditions. However, in synthetic materials chemistry, introduced chemical moieties are usually monofunctional, either being adhesive or cohesive; typically, this is not effective compared to natural materials. Herein, it is demonstrated that hyaluronic acid-catechol (HA-catechol) conjugates can exhibit either adhesiveness, functionalizing the surface of materials, or cohesiveness, building 3D hydrogels. Up to now, catechol-conjugated polymers have shown to be useful in one of these two functions. The usefulness of the polymer in stem cell engineering is demonstrated. A platform for neural stem cell culture may be prepared, utilizing the adhesive property of HA-catechol, and hydrogels are fabricated to encapsulate the neural stem cells, utilizing the cohesive property of the HA conjugate. Moreover, the HA-catechol hydrogels are highly neural stem cell compatible, showing better viability compared to existing methods based on HA hydrogels. Hyaluronic acid catechol conjugate is able to change between adhesiveness and cohesiveness in a smart way. This is demonstrated to be useful for human neural stem cell culture, which cannot be stably cultured on typical polystyrene culture plates.
KW - adhesion
KW - catechol
KW - cohesion
KW - mussels
KW - neural stem cells
UR - http://www.scopus.com/inward/record.url?scp=84875844012&partnerID=8YFLogxK
U2 - 10.1002/adfm.201202365
DO - 10.1002/adfm.201202365
M3 - Article
AN - SCOPUS:84875844012
SN - 1616-301X
VL - 23
SP - 1774
EP - 1780
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 14
ER -