Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Hyun Jung Kim; Sukmook Lee; Yong Seok Oh; Ha Kyun Chang; Young Sang Kim; Sung Hee Hong; Jung Yong Kim; Young Whan Park; Song Jae Lee; Seong Won Song; Jung Ju Kim; Kyun Heo

doi:10.3389/fonc.2019.00571

Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Hyun Jung Kim, Sukmook Lee, Yong Seok Oh, Ha Kyun Chang, Young Sang Kim, Sung Hee Hong, Jung Yong Kim, Young Whan Park, Song Jae Lee, Seong Won Song, Jung Ju Kim, Kyun Heo

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.

Original language	English
Article number	571
Journal	Frontiers in Oncology
Volume	9
DOIs	https://doi.org/10.3389/fonc.2019.00571
State	Published - 9 Jul 2019

Bibliographical note

Publisher Copyright:
Copyright © 2019 Kim, Lee, Oh, Chang, Kim, Hong, Kim, Park, Lee, Song, Kim and Heo.

Keywords

HGF
YYB-101
humanized monoclonal antibody
metastasis
ovarian cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2019.00571

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title = "Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression",

abstract = "Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.",

keywords = "HGF, YYB-101, humanized monoclonal antibody, metastasis, ovarian cancer",

author = "Kim, {Hyun Jung} and Sukmook Lee and Oh, {Yong Seok} and Chang, {Ha Kyun} and Kim, {Young Sang} and Hong, {Sung Hee} and Kim, {Jung Yong} and Park, {Young Whan} and Lee, {Song Jae} and Song, {Seong Won} and Kim, {Jung Ju} and Kyun Heo",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 Kim, Lee, Oh, Chang, Kim, Hong, Kim, Park, Lee, Song, Kim and Heo.",

year = "2019",

month = jul,

day = "9",

doi = "10.3389/fonc.2019.00571",

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AU - Kim, Hyun Jung

AU - Lee, Sukmook

AU - Oh, Yong Seok

AU - Chang, Ha Kyun

AU - Kim, Young Sang

AU - Hong, Sung Hee

AU - Kim, Jung Yong

AU - Park, Young Whan

AU - Lee, Song Jae

AU - Song, Seong Won

AU - Kim, Jung Ju

AU - Heo, Kyun

PY - 2019/7/9

Y1 - 2019/7/9

N2 - Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.

AB - Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an in vivo ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.

KW - HGF

KW - YYB-101

KW - humanized monoclonal antibody

KW - metastasis

KW - ovarian cancer

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U2 - 10.3389/fonc.2019.00571

DO - 10.3389/fonc.2019.00571

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AN - SCOPUS:85085894828

SN - 2234-943X

VL - 9

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 571

ER -

Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression

Abstract

Bibliographical note

Keywords

UN SDGs

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