Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

Ji Ae Park; Hee Kyung Kim; Joo Hyun Kim; Sang Won Jeong; Jae Chang Jung; Gang Ho Lee; Jongmin Lee; Yongmin Chang; Tae Jeong Kim

doi:10.1016/j.bmcl.2010.02.002

Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

Ji Ae Park, Hee Kyung Kim, Joo Hyun Kim, Sang Won Jeong, Jae Chang Jung, Gang Ho Lee, Jongmin Lee, Yongmin Chang, Tae Jeong Kim

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 10³ per particles, and they demonstrate very high R1 relaxivity (∼10⁵ mM^-1 s^-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM^-1 s^-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

Original language	English
Pages (from-to)	2287-2291
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2010.02.002
State	Published - 1 Apr 2010

Bibliographical note

Funding Information:
Financial support from The Advanced Medical Technology Cluster for Diagnosis & Prediction , KNU from MKE, ROK (Grant No. RTI04-01-01 ) is gratefully acknowledged. The MEST/NRF is also acknowledged for the financial support through the Nuclear R&D Program. Nuclear R&D Program (Grant code: 20090081817) of NRF funded by MEST . Spectral measurements were performed by the KBSI.

Keywords

DTPA-cysteine
Gadolinium chelate
Gold nanoparticles
MRI-CT bimodality
T1 agent

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10.1016/j.bmcl.2010.02.002

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title = "Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent",

abstract = "The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.",

keywords = "DTPA-cysteine, Gadolinium chelate, Gold nanoparticles, MRI-CT bimodality, T1 agent",

author = "Park, {Ji Ae} and Kim, {Hee Kyung} and Kim, {Joo Hyun} and Jeong, {Sang Won} and Jung, {Jae Chang} and Lee, {Gang Ho} and Jongmin Lee and Yongmin Chang and Kim, {Tae Jeong}",

note = "Funding Information: Financial support from The Advanced Medical Technology Cluster for Diagnosis & Prediction , KNU from MKE, ROK (Grant No. RTI04-01-01 ) is gratefully acknowledged. The MEST/NRF is also acknowledged for the financial support through the Nuclear R&D Program. Nuclear R&D Program (Grant code: 20090081817) of NRF funded by MEST . Spectral measurements were performed by the KBSI. ",

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doi = "10.1016/j.bmcl.2010.02.002",

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AU - Park, Ji Ae

AU - Kim, Hee Kyung

AU - Kim, Joo Hyun

AU - Jeong, Sang Won

AU - Jung, Jae Chang

AU - Lee, Gang Ho

AU - Lee, Jongmin

AU - Chang, Yongmin

AU - Kim, Tae Jeong

N1 - Funding Information: Financial support from The Advanced Medical Technology Cluster for Diagnosis & Prediction , KNU from MKE, ROK (Grant No. RTI04-01-01 ) is gratefully acknowledged. The MEST/NRF is also acknowledged for the financial support through the Nuclear R&D Program. Nuclear R&D Program (Grant code: 20090081817) of NRF funded by MEST . Spectral measurements were performed by the KBSI.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

AB - The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

KW - DTPA-cysteine

KW - Gadolinium chelate

KW - Gold nanoparticles

KW - MRI-CT bimodality

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Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

Abstract

Bibliographical note

Keywords

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