Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers

Hyehyeon Kim; Saehee Kim; Chiyoung Park; Hyemi Lee; Heon Joo Park; Chulhee Kim

doi:10.1002/adma.201001417

Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers

Hyehyeon Kim, Saehee Kim, Chiyoung Park, Hyemi Lee, Heon Joo Park, Chulhee Kim

Department of Energy and Science and Engineering

Inha University

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

Abstract

Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.

Original language	English
Pages (from-to)	4280-4283
Number of pages	4
Journal	Advanced Materials
Volume	22
Issue number	38
DOIs	https://doi.org/10.1002/adma.201001417
State	Published - 8 Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/adma.201001417

Cite this

@article{c40bf1983fef425e8e98620969d9be97,

title = "Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers",

abstract = "Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.",

author = "Hyehyeon Kim and Saehee Kim and Chiyoung Park and Hyemi Lee and Park, {Heon Joo} and Chulhee Kim",

year = "2010",

month = oct,

day = "8",

doi = "10.1002/adma.201001417",

language = "English",

volume = "22",

pages = "4280--4283",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "38",

}

TY - JOUR

T1 - Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers

AU - Kim, Hyehyeon

AU - Kim, Saehee

AU - Park, Chiyoung

AU - Lee, Hyemi

AU - Park, Heon Joo

AU - Kim, Chulhee

PY - 2010/10/8

Y1 - 2010/10/8

N2 - Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.

AB - Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.

UR - http://www.scopus.com/inward/record.url?scp=77957898000&partnerID=8YFLogxK

U2 - 10.1002/adma.201001417

DO - 10.1002/adma.201001417

M3 - Article

C2 - 20803535

AN - SCOPUS:77957898000

SN - 0935-9648

VL - 22

SP - 4280

EP - 4283

JO - Advanced Materials

JF - Advanced Materials

IS - 38

ER -

Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this