Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests

Chiyoung Park; Hyehyeon Kim; Saehee Kim; Chulhee Kim

doi:10.1021/ja9061085

Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests

Chiyoung Park, Hyehyeon Kim, Saehee Kim, Chulhee Kim

Department of Energy and Science and Engineering

Inha University

Research output: Contribution to journal › Article › peer-review

371 Scopus citations

Abstract

(Figure Presented) The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.

Original language	English
Pages (from-to)	16614-16615
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	46
DOIs	https://doi.org/10.1021/ja9061085
State	Published - 2009

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abstract = "(Figure Presented) The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.",

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N2 - (Figure Presented) The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.

AB - (Figure Presented) The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.

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Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests

Abstract

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