Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles

Bo Ram Lee; Hye Rim Kim; Eun Sook Choi; Jung Hoon Cho; Nam Jun Kim; Jung Hee Kim; Kyeong Min Lee; Abdul Razzaq; Hansaem Choi; Yunju Hwang; Craig A. Grimes; Bong Hyo Lee; Eunjoo Kim; Su Il In

doi:10.1038/s41598-017-11213-0

Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles

Bo Ram Lee, Hye Rim Kim, Eun Sook Choi, Jung Hoon Cho, Nam Jun Kim, Jung Hee Kim, Kyeong Min Lee, Abdul Razzaq, Hansaem Choi, Yunju Hwang, Craig A. Grimes, Bong Hyo Lee, Eunjoo Kim, Su Il In

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9 Scopus citations

Abstract

Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats. Herein, we investigate molecular changes in colorectal cancer (CRC) rats by acupuncture treatment using the nanoporous needles. Treatment at acupoint HT7 is found most effective at reducing average tumor size, β-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Surface modification of acupuncture needles further enhances the therapeutic effects of acupuncture treatment in CRC rats.

Original language	English
Article number	12900
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-11213-0
State	Published - 1 Dec 2017

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Publisher Copyright:
© 2017 The Author(s).

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title = "Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles",

abstract = "Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats. Herein, we investigate molecular changes in colorectal cancer (CRC) rats by acupuncture treatment using the nanoporous needles. Treatment at acupoint HT7 is found most effective at reducing average tumor size, β-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Surface modification of acupuncture needles further enhances the therapeutic effects of acupuncture treatment in CRC rats.",

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AU - Cho, Jung Hoon

AU - Kim, Nam Jun

AU - Kim, Jung Hee

AU - Lee, Kyeong Min

AU - Razzaq, Abdul

AU - Choi, Hansaem

AU - Hwang, Yunju

AU - Grimes, Craig A.

AU - Lee, Bong Hyo

AU - Kim, Eunjoo

AU - In, Su Il

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Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles

Abstract

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