Enantioselective conjugate radical addition to α′-hydroxy enones

(Chemical Equation Presented) Enantioselective conjugate radical addition to α′-hydroxy α,β-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to α′-hydroxy α,β-unsaturated ketones in the presence of Mg(NTf₂)₂ and bisoxazoline ligand 5a proceeded cleanly, yielding the addition products in high chemical yields and good enantiomeric excesses.