Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo; Hong Jae Lee; Sung Eun Kim; Jeong Ho Chang; Chiyoung Park; Chulhee Kim; Jae Hyung Park; Sang Cheon Lee

doi:10.1039/b815918a

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo
, Hong Jae Lee
, Sung Eun Kim
, Jeong Ho Chang
, Chiyoung Park
, Chulhee Kim
, Jae Hyung Park
, Sang Cheon Lee

Department of Energy and Science and Engineering

Research output: Contribution to journal › Article › peer-review

395 Scopus citations

Abstract

We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Original language	English
Pages (from-to)	6570-6572
Number of pages	3
Journal	Chemical Communications
Issue number	48
DOIs	https://doi.org/10.1039/b815918a
State	Published - 2008

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10.1039/b815918a

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@article{115061bec09b44d886f323dac67ce4fc,

title = "Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery",

abstract = "We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.",

author = "Koo, \{Ahn Na\} and Lee, \{Hong Jae\} and Kim, \{Sung Eun\} and Chang, \{Jeong Ho\} and Chiyoung Park and Chulhee Kim and Park, \{Jae Hyung\} and Lee, \{Sang Cheon\}",

year = "2008",

doi = "10.1039/b815918a",

language = "English",

pages = "6570--6572",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "48",

}

TY - JOUR

T1 - Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

AU - Koo, Ahn Na

AU - Lee, Hong Jae

AU - Kim, Sung Eun

AU - Chang, Jeong Ho

AU - Park, Chiyoung

AU - Kim, Chulhee

AU - Park, Jae Hyung

AU - Lee, Sang Cheon

PY - 2008

Y1 - 2008

N2 - We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

AB - We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

UR - https://www.scopus.com/pages/publications/57349111147

U2 - 10.1039/b815918a

DO - 10.1039/b815918a

M3 - Article

C2 - 19057782

AN - SCOPUS:57349111147

SN - 1359-7345

SP - 6570

EP - 6572

JO - Chemical Communications

JF - Chemical Communications

IS - 48

ER -

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Abstract

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