Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo, Hong Jae Lee, Sung Eun Kim, Jeong Ho Chang, Chiyoung Park, Chulhee Kim, Jae Hyung Park, Sang Cheon Lee

Research output: Contribution to journalArticlepeer-review

386 Scopus citations

Abstract

We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Original languageEnglish
Pages (from-to)6570-6572
Number of pages3
JournalChemical Communications
Issue number48
DOIs
StatePublished - 2008

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