Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface

Sanghoon Lee; Hao Wang; Wendy Yen Xian Peh; Nitish V. Thakor; Shih Cheng Yen; Chengkuo Lee

doi:10.1109/NER.2019.8716975

Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface

Sanghoon Lee
, Hao Wang
, Wendy Yen Xian Peh
, Nitish V. Thakor
, Shih Cheng Yen
, Chengkuo Lee

Department of Robotics and Mechatronics Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Scopus citations

Abstract

This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.

Original language	English
Title of host publication	9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Publisher	IEEE Computer Society
Pages	706-709
Number of pages	4
ISBN (Electronic)	9781538679210
DOIs	https://doi.org/10.1109/NER.2019.8716975
State	Published - 16 May 2019
Event	9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States Duration: 20 Mar 2019 → 23 Mar 2019

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2019-March
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Conference

Conference	9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Country/Territory	United States
City	San Francisco
Period	20/03/19 → 23/03/19

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

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10.1109/NER.2019.8716975

Cite this

Lee, S., Wang, H., Peh, W. Y. X., Thakor, N. V., Yen, S. C., & Lee, C. (2019). Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 (pp. 706-709). Article 8716975 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March). IEEE Computer Society. https://doi.org/10.1109/NER.2019.8716975

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title = "Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface",

abstract = "This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.",

author = "Sanghoon Lee and Hao Wang and Peh, \{Wendy Yen Xian\} and Thakor, \{Nitish V.\} and Yen, \{Shih Cheng\} and Chengkuo Lee",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 ; Conference date: 20-03-2019 Through 23-03-2019",

year = "2019",

month = may,

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doi = "10.1109/NER.2019.8716975",

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Lee, S, Wang, H, Peh, WYX, Thakor, NV, Yen, SC & Lee, C 2019, Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface. in 9th International IEEE EMBS Conference on Neural Engineering, NER 2019., 8716975, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2019-March, IEEE Computer Society, pp. 706-709, 9th International IEEE EMBS Conference on Neural Engineering, NER 2019, San Francisco, United States, 20/03/19. https://doi.org/10.1109/NER.2019.8716975

Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface. / Lee, Sanghoon; Wang, Hao; Peh, Wendy Yen Xian et al.
9th International IEEE EMBS Conference on Neural Engineering, NER 2019. IEEE Computer Society, 2019. p. 706-709 8716975 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lee, Chengkuo

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N2 - This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.

AB - This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.

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Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface

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