Abstract
Statement of Purpose: Removal of cancer cells in blood system is an important therapeutics for leukemia patients. Chemotherapy has been widely used to remove cancer cells in blood stream, however, side effects has been a serious problem in the process. In this study, leukemia cell-specific removal directly in blood stream was performed in a leukemia animal model, AKR mouse, by using target-specific magnetic hyperthermia. Magnetic hyperthermia has been widely reported in animal xenograft model, and most of them were performed to reduce tumor cell masses artificially prepared in mouse body. This study proposes a possible method to treat genetically modified animal model of leukemia by treatment of iron oxide magnetic particles modified with a specific antibody targeted to leukemia cells, anti-EpCAM antibody, and subsequent irradiation of magnetic field to whole body of animals. Heat induction by iron oxide nanoparticles under magnetic field induced the removal of attached leukemia cells on the iron oxide nanoparticles.
| Original language | English |
|---|---|
| Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
| Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
| Publisher | Society for Biomaterials |
| Pages | 804 |
| Number of pages | 1 |
| ISBN (Electronic) | 9781510883901 |
| State | Published - 2019 |
| Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 3 Apr 2019 → 6 Apr 2019 |
Publication series
| Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
|---|---|
| Volume | 40 |
| ISSN (Print) | 1526-7547 |
Conference
| Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
|---|---|
| Country/Territory | United States |
| City | Seattle |
| Period | 3/04/19 → 6/04/19 |
Bibliographical note
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