Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

Regine Choe; Alper Corlu; Kijoon Lee; Turgut Durduran; Soren D. Konecky; Monika Grosicka-Koptyra; Simon R. Arridge; Brian J. Czerniecki; Douglas L. Fraker; Angela Demichele; Britton Chance; Mark A. Rosen; Arjun G. Yodh

doi:10.1118/1.1869612

Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

Regine Choe
, Alper Corlu
, Kijoon Lee
, Turgut Durduran
, Soren D. Konecky
, Monika Grosicka-Koptyra
, Simon R. Arridge
, Brian J. Czerniecki
, Douglas L. Fraker
, Angela Demichele
, Britton Chance
, Mark A. Rosen
, Arjun G. Yodh

Department of Electrical Engineering and Computer Science

Research output: Contribution to journal › Article › peer-review

291 Scopus citations

Abstract

We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.

Original language	English
Pages (from-to)	1128-1139
Number of pages	12
Journal	Medical Physics
Volume	32
Issue number	4
DOIs	https://doi.org/10.1118/1.1869612
State	Published - Apr 2005

Bibliographical note

Funding Information:
The authors thank J. P. Culver for his work on the instrumentation and for helpful discussions. The authors also thank L. Sherman for her contribution as clinical research assistant and Y. K. Choe for his help with illustrations. This research was supported by NIH R01-CA75124-04 and CALGB150007/150012.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Breast imaging
Diffuse optical tomography
Near infrared imaging
Neoadjuvant chemotherapy

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10.1118/1.1869612

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Choe, R., Corlu, A., Lee, K., Durduran, T., Konecky, S. D., Grosicka-Koptyra, M., Arridge, S. R., Czerniecki, B. J., Fraker, D. L., Demichele, A., Chance, B., Rosen, M. A., & Yodh, A. G. (2005). Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI. Medical Physics, 32(4), 1128-1139. https://doi.org/10.1118/1.1869612

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title = "Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI",

abstract = "We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.",

keywords = "Breast cancer, Breast imaging, Diffuse optical tomography, Near infrared imaging, Neoadjuvant chemotherapy",

author = "Regine Choe and Alper Corlu and Kijoon Lee and Turgut Durduran and Konecky, \{Soren D.\} and Monika Grosicka-Koptyra and Arridge, \{Simon R.\} and Czerniecki, \{Brian J.\} and Fraker, \{Douglas L.\} and Angela Demichele and Britton Chance and Rosen, \{Mark A.\} and Yodh, \{Arjun G.\}",

note = "Funding Information: The authors thank J. P. Culver for his work on the instrumentation and for helpful discussions. The authors also thank L. Sherman for her contribution as clinical research assistant and Y. K. Choe for his help with illustrations. This research was supported by NIH R01-CA75124-04 and CALGB150007/150012.",

year = "2005",

month = apr,

doi = "10.1118/1.1869612",

language = "English",

volume = "32",

pages = "1128--1139",

journal = "Medical Physics",

issn = "0094-2405",

publisher = "John Wiley and Sons Ltd",

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T1 - Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy

T2 - A case study with comparison to MRI

AU - Choe, Regine

AU - Corlu, Alper

AU - Lee, Kijoon

AU - Durduran, Turgut

AU - Konecky, Soren D.

AU - Grosicka-Koptyra, Monika

AU - Arridge, Simon R.

AU - Czerniecki, Brian J.

AU - Fraker, Douglas L.

AU - Demichele, Angela

AU - Chance, Britton

AU - Rosen, Mark A.

AU - Yodh, Arjun G.

N1 - Funding Information: The authors thank J. P. Culver for his work on the instrumentation and for helpful discussions. The authors also thank L. Sherman for her contribution as clinical research assistant and Y. K. Choe for his help with illustrations. This research was supported by NIH R01-CA75124-04 and CALGB150007/150012.

PY - 2005/4

Y1 - 2005/4

N2 - We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.

AB - We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.

KW - Breast cancer

KW - Breast imaging

KW - Diffuse optical tomography

KW - Near infrared imaging

KW - Neoadjuvant chemotherapy

UR - https://www.scopus.com/pages/publications/17844409108

U2 - 10.1118/1.1869612

DO - 10.1118/1.1869612

M3 - Article

C2 - 15895597

AN - SCOPUS:17844409108

SN - 0094-2405

VL - 32

SP - 1128

EP - 1139

JO - Medical Physics

JF - Medical Physics

IS - 4

ER -

Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

Abstract

Bibliographical note

UN SDGs

Keywords

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