Design and simulation of a neural interface based on a microfluidic flexible interconnection cable for chemical delivery

Neural interfaces are fundamental tools for transmitting information from the nervous system. Research on the immune response of an invasive neural interface is a field that requires continuous effort. Various efforts have been made to overcome or minimize limitations through modifying the designs and materials of neural interfaces, modifying surface characteristics, and adding functions to them. In this study, we demonstrate microfluidic channels with crater-shaped structures fabricated using parylene-C membranes for fluid delivery from the perspective of theory, design, and simulation. The simulation results indicated that the fluid flow depended on the size of the outlet and the alignment of microstructures inside the fluidic channel. All the results can be used to support the design of microfluidic channels made by membranes for drug delivery.