Decarboxylative C-H arylation of benzoic acids under radical conditions

Sangwon Seo; Mark Slater; Michael F. Greaney

doi:10.1021/ol3010694

Decarboxylative C-H arylation of benzoic acids under radical conditions

Sangwon Seo, Mark Slater, Michael F. Greaney

Department of Physics and Chemistry

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K ₂S ₂O ₈ to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

Original language	English
Pages (from-to)	2650-2653
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	10
DOIs	https://doi.org/10.1021/ol3010694
State	Published - 18 May 2012

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title = "Decarboxylative C-H arylation of benzoic acids under radical conditions",

abstract = "A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K 2S 2O 8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.",

author = "Sangwon Seo and Mark Slater and Greaney, {Michael F.}",

year = "2012",

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doi = "10.1021/ol3010694",

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AU - Slater, Mark

AU - Greaney, Michael F.

PY - 2012/5/18

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N2 - A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K 2S 2O 8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

AB - A decarboxylative radical cyclization reaction has been developed for the synthesis of fluorenones. The reaction uses Ag(I)/K 2S 2O 8 to oxidatively decarboxylate an aroylbenzoic acid to an aryl radical, which undergoes cyclization to afford fluorenone products in good yield.

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U2 - 10.1021/ol3010694

DO - 10.1021/ol3010694

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JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Decarboxylative C-H arylation of benzoic acids under radical conditions

Abstract

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